When switching from manga style storyboard to 4 koma, I ended up with some color changes. I'm still not entirely sure how much of these was thematic or just personal taste. Here is the chart:
( I know those look like underwear patches, but those are charcoal swatches. )
For example mineral green, the closest to black that I could get with calligraphy pens, shifted to more of a brownish black. A dark sepia like orange shifted to to more of a blood red. I have a vague idea about how the shades of cyan and baby blue came about, and to an extent red and blond. But I'm still not entirely sure how the specific shade of purple came about.
Hemato is suppose to wear all black, and sometimes feature blood red. Ehena is suppose to wear khaki pants and birkenstocks, and baby blue tees, with a large blue bow. Mostly I'm not sure how much of these colors are going to translate if I were to ever shift to network television.
The closest ( genre wise ) show I can think of, Hey Arnold, was published back when Nickelodeon was still Nick. But my color palette is very different from the standard slice of life.
Ironically, the original palette would be more fitting for Nickelodeon, despite the darkness of the web comic itself.